|
KMID : 0613820080180030357
|
|
Journal of Life Science
2008 Volume.18 No. 3 p.357 ~ p.362
|
|
|
Effects of Aralia continentalis Kitagawa on Antiplatelet and Antioxidative Activities
|
|
Yang Seun-Ah
Im Nam-Kyung
Jhee Kwang-Hwan
Lee In-Seon
|
|
|
Abstract
|
|
|
|
The dried roots of Aralia continentalis Kitagawa is known to have the potential for anti-inflammation and anti-rheumatic, but their effects on thrombosis are not clear. In this study, we evaluated the anti-platelet and antioxidative activities of A. continentalis Kitagawa. Methanol extract and its various fractions of A. continentalis Kitagawa inhibited ADP-induced platelet aggregation, and EtOAc fraction showed strongest inhibition in a concentration-dependent manner with a IC50 value of 217.7 μg/mL . Moreover, the EtOAc fraction contained 77.7% of 1,1-diphenyl-2-picrylhydrazyl(DPPH) and 43.1% of 2,2’-azinobis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical-scavenging activity at 0.1 mg/ml. In addition, the methanol and EtOAc fraction dose-dependently inhibited thrombin-stimulated platelet adhesion to collagen or fibrinogen. Collectively, these results suggest that the polyphenol-rich EtOAc fraction from A. continentalis Kitagawa can reduce platelet hyperactivation by scavenging free radicals. Thus, the EtOAc fraction of A. continentalis Kitagawa is a potential source for inhibition of platelet-dependent thrombosis.
|
|
|
KEYWORD
|
|
|
Aralia continentalis Kitagawa, platelet aggregation, platelet adhesion, antioxidant
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|